df.drop_duplicates(subset=['Variable','Value'],keep='first')# time Variable Value#2014-07-11 19:50:20 Var1 10#2014-07-11 19:50:30 Var1 20#2014-07-11 19:50:50 Var2 30#2014-07-11 19:50:60 Var2 40#2014-07-11 19:50:70 Var2 50

df.drop_duplicates(subset=['Variable','Value'],keep='first')# time Variable Value#2014-07-11 19:50:20 Var1 10#2014-07-11 19:50:30 Var1 20#2014-07-11 19:50:50 Var2 30#2014-07-11 19:50:60 Var2 40#2014-07-11 19:50:70 Var2 50