请尝试以下方法：
chromeOptions = webdriver.ChromeOptions()prefs = {"plugins.always_open_pdf_externally": True}chromeOptions.add_experimental_option("prefs",prefs)driver = webdriver.Chrome(chrome_options=chromeOptions)driver.get('https://www.southtechhosting.com/SanJoseCity/CampaignDocsWebRetrieval/Search/SearchByElection.aspx')#Code to open the pop-updriver.find_element_by_xpath('//*[@id="ctl00_DefaultContent_ASPxRoundPanel1_btnFindFilers_CD"]').click()driver.find_element_by_xpath('//*[@id="ctl00_GridContent_gridFilers_DXCBtn0"]').click()driver.find_element_by_xpath('//*[@id="ctl00_DefaultContent_gridFilingForms_DXCBtn0"]').click()driver.switch_to.frame(driver.find_element_by_tag_name('iframe'))a = driver.find_element_by_link_text("Click here")ActionChains(driver).key_down(Keys.CONTROL).click(a).key_up(Keys.CONTROL).perform()更新：要退出弹出窗口，可以尝试以下操作：
driver.switch_to.default_content()driver.find_element_by_xpath('//*[@id="ctl00_GenericPopupSizeable_InnerPopupControl_HCB-1"]/img').click()
