罗虹
[摘要]目的 探討桂哌齐特与甲钴胺对糖尿病周围神经病变（DPN）患者神经传导速度、VPT及血清指标的影响。方法 选取2015年3月～2017年3月我院收治的80例DPN患者作为研究对象，按照平行对照法分为观察组（桂哌齐特与甲钴胺治疗）与参考组（甲钴胺治疗），每组各40例。比较两组患者治疗前后的神经传导速度、双下肢震动感觉阈值（VPT）水平以及血清指标变化。结果 治疗前后两组患者的神经传导速度比较，差异有统计学意义（P<0.05）；治疗后观察组各部位的神经传导速度明显大于参考组，差异有统计学意义（P<0.05）；治疗前后两组患者VPT值比较，差异有统计学意义（P<0.05）；治疗后观察组的下降程度大于参考组，差异有统计学意义（P<0.05）；治疗前后两组患者血清HMGB1、Hcy、MDA、NSE、S100β水平比较，差异有统计学意义（P<0.05）；观察组与参考组各指标比较，差异有统计学意义（P<0.05）。结论 桂哌齐特与甲钴胺联合治疗DPN能够促进患者微循环改善，促进受损神经功能的恢复，效果显著。
[关键词]桂哌齐特；甲钴胺；DPN；神经传导速度；VPT；血清指标
[中图分类号] R587.2 [文献标识码] A [文章编号] 1674-4721（2018）4（b）-0050-04
Effect of Cinepazide and Mecobalamin on nerve conduction velocity，VPT and serum parameters in patients with diabetic peripheral neuropathy
LUO Hong
Department of Endocrinology，the First People′s Hospital of Fuzhou City in Jiangxi Province，Fuzhou 344000，China
[Abstract]Objective To investigate the effects of Cinepazide and Mecobalamin on the nerve conduction velocity，vibration perception threshold （VPT） and serum parameters in diabetic peripheral neuropathy （DPN） patients.Methods Eighty DPN patients treated in our hospital from March 2015 to March 2017 were selected as the subjects，and divided into observation group （Cinepazide and Mecobalamin therapy） and reference group （sole Mecobalamin），with 40 cases in each group according to the method of parallel control.The nerve conduction velocity，the VPT level and serum parameters before and after treatment were compared between the two groups.Results Before and after treatment，the nerve conduction velocity was significantly different between the two groups （P<0.05）.After the treatment，the nerve conduction velocity in various parts in the observation group was significantly greater than that of the reference group，the difference was statistically significant （P<0.05）.The VPT values of the two groups before and after treatment were significantly different （P<0.05）.After treatment，the decrease of VPT in the observation group was more remarkable compared with that in the reference group （P<0.05）.The levels of serum HMGB1，Hcy，MDA，NSE and S100β in the two groups before and after treatment were significantly different （P<0.05）.Each parameter in the observation group was statistically different from that in the reference group （P<0.05）.Conclusion Combination of cinepazide and mecobalamin in the treatment of DPN can promote microcirculation and recovery of damaged nerve function，and obtain a remarkable effect.
[Key words]Cinepazide；Mecobalamin；DPN；Nerve conduction velocity；VPT；Serum parameters
