英语翻译9-(2-Methylphenyl)-3,4,5,6,9,10-hexahydroxanthene-1,8(2H

英语翻译9-(2-Methylphenyl)-3,4,5,6,9,10-hexahydroxanthene-1,8(2H,7H)-dioneMarco Brito-Arias,(1) Manuel Tapia-Albarra´ n,(1) Itzia Padilla-Martı´nez,(1) FranciscoMartı´nez-Martı´nez,(1) Georgina Espinosa,(2) Elies Molins,(3)* and Enrique EspinosaExperimental sectionOur general approach uses 1,3-cyclohexanedione(1) and ortho substituted benzaldehydes (2a–d)as starting materials,which were condensed withKOH in EtOHUH2O media to generate intermediate(3),which is further reacted with sodium methoxidesolution at room temperature to afford (4).Thisreaction can also be carried out straightforwardly byreacting (1) and (2) with sodium methoxide solutionto directly produce (4) in 60% yield.The 1H NMRspectroscopy displays similar signal pattern inagreement with the X-ray structure obtained.Thus,for (4b) (CDCl3):d 2.0 (4H,t),2.3 (4H,m),2.7 (4H,t),2.9 (3H,s),5.0 (1H,s),7.0–7.6 (4H,m).It isnoteworthy to mention that the dimeric intermediate(3),which we have been able to isolate,is a keyintermediate for the preparation of the heterocyclicthree ring systems (4),(5),and (6) that we have reportedso far.Therefore,depending on the systemrequested (either the xanthendione (4),the acridindione(5),or the acridone (6) derivatives),the intermediate(3) must be treated with sodium methoxidesolution,with amines or sodium azide,and with ironin acid,respectively.The structure of the title compound was solvedby direct methods.Refinement was based on fullmatrixleast-squares methods,with anisotropic displacementparameters for all non-H atoms and aglobal fixed isotropic displacement parameter for Hatoms.Hatoms were included at calculated positions,using a riding model.Table 1 shows crystal data andthe structure refinement parameters correspondingto the x-ray diffraction analysis.