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翻译这种文章太费时间了, 强烈要求加分! 筛选出和FGFR3结合的活性短肽 The selection of active peptide binding with FGFR3 ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关； The BMSC osteogenic activities of ACH mice enhanced, mineralization capability reduced, these are related to the Cbfa1, OP expression promoted by FGFR3 with ERK1/2。 FGFR3、1均直接及经成骨细胞促进破骨细胞分化及吸收功能 Directly and through the osteoblasts, FGFR 3 and 1 both promoted the differentiation and absorption functions of the osteoclasts。 FGFR3与h1-calponin、ALK3等有crosstalk,共同调节骨骼发育及骨稳定 FGFR3 and h1-calponin, ALK3 all possessed crosswalk and jointly regulated skeletal growth and stability。 用条件性基因敲除技术发现FGFR1抑制成骨细胞增生、分化,成骨细胞敲除FGFR1的小鼠骨量增加,有自发骨折,ALK3降低在其中起重要作用 By applying conditional gene knockout technique, it was found that FGFR1 inhibited the hyperplasia and differentiation of osteoblasts; and bone mass increase and spontaneous fracture were observed on the osteoblast knockout FGFR1 mice, the reduction of ALK3 was an important factor。 在破骨细胞敲除FGFR1的小鼠骨量增加,骨折愈合延迟 Increase in bone mass and delay on fracture healing were observed on the osteoclast knockout FGFR1 mice。 用基因敲入技术建立模拟人Apert综合症的小鼠模型,发现FGFR2突变经ERK1/2同时影响软骨及成骨细胞发育导致囟门早闭 On the mice model simulating Apert Syndrome on human obtained by using the gene knock-in technique, mutation was found in FGFR2 with ERK1/2, at the same time affecting the development of cartilage and osteoblasts resulting in early fontanel closure。 建立FGFR3条件性敲除小鼠及其它10余种转基因小鼠模型。 Establish FGFR3 conditional knockout mice and more than ten other transgenic mice models。