Following the second part (see Fig.1) solves this mixture de

Following the second part (see Fig.1) solves this mixture design problem,as stated in the methodology (see section 2).Pure component solvents and anti-solvents are designed first and then optimal solvent-anti solvent binary mixture is identified.Since solvents and anti-solvents perform different roles and hence have different property constraints two molecular design problems need to be formulated and solved.As stated in the methodology the first three sub-problems pertain to pure component design.For the pure component solvent design,the structural constraints are considered in the first sub-problem.In the second sub-problem all feasible molecular structures were solved for the four pure component property constraints of the solvent namely boiling point,melting point,total solubility parameter and hydrogen bonding solubility parameter.Since we do not have mixture property constraints regarding pure solvents we do not need the third sub-problem in the methodology.The same applies to the three sub- problems of the pure component anti-solvent design where anti-solvent property constraints namely boiling point,melting point and solubility parameter are considered.Then the fourth sub-problem as per the methodology is solved where the pure component solvents and anti solvents are verified for the binary miscibility.In this case study the process model constraints are not considered and hence we do not need the final sub-problem.Now the optimal solvent is selected by evaluating the performance index (objective function) of all the binary solvent - anti solvent mixtures that satisfied all the sub-problems.The sub problems have been solved with the ProCAMD toolbox in ICAS (ICAS Documentations,2002).