请问and连接两个主语时,变否定句跟一般疑问句,是不是也一定要把and变成or?请举例说明

要看and连接两个主语在整个句子中做主语还是宾语,主语不变 宾语变例句1：Teachers and students are good friends。Are teacher and students good friends?Teachers and students are not good friends。例句2：They are good class and friends。They are not good class or friends。Are they good class or friends。