英语翻译Our study also addressed the role of extrinsic in-nervat

英语翻译Our study also addressed the role of extrinsic in-nervation in postprandial absorption.The study wasdesigned to determine whether extrinsic innervationplays a role in mediating postprandial augmenta-tion in net absorptions.Net ileal absorption of glu-cose and glutamine in the early postprandial periodwas decreased.These decreases in absorption werenot a nonspecific global event,because there was nopostprandial effect on absorption of oleic acid or taur-ocholate at any time point.Also,there were no grosschanges in transit after feeding that might explain adecrease in absorption.In addition,although we didnot evaluate intestinal morphology in this experi-ment,we have shown previously that gross mucosalmorphology does not change with this preparation.Our previous work and that of others have re-peatedly shown a marked weight loss after in situneural isolation(extrinsic denervation)of the jeju-noileumand after jejunoileal autotransplanta-tion.23,24 The primary cause or causes of this weightloss have remained elusive.Multiple studies of netabsorptive function in the whole dog and specificallyin jejunum17,25 and ileum18,26 have shown statisti-cally significant although relatively minor decreaseson baseline absorption during fasting that do notappear great enough alone to explain either the pro-fuse watery diarrhea or the weight loss that aresoprominent in the first 2 to 3 weeks after these modelsof small bowel autotransplantation.The decrease innet absorption of the simple solutes(glucose,gluta-mine)in the early postprandial period may help toexplain these previous observations.Also of interest isthe finding that this postprandial decrease is transient.Early postprandial net absorption had returned tonormal when measured at 12 weeks after extrinsicdenervation,a time when the watery diarrhea hadalso resolved and the dogs had regained the weightthey lost in the early postoperative period.Thispostprandial decrease in net absorption may havetranslational importance in the field of clinical SBT.Weight loss and diarrhea occur after SBT in humans,and the mechanism(s)remains largely unknown